Pesquisa | BVS Doenças Infecciosas e Parasitárias

1.

Plaque attack by microglial PLCÎ³2.

Comer, Ashley L; Hammond, Timothy R.

Immunity ; 56(9): 1985-1987, 2023 09 12.

Artigo em Inglês | MEDLINE | ID: mdl-37703828

2.

Microglia and the Brain: Complementary Partners in Development and Disease.

Hammond, Timothy R; Robinton, Daisy; Stevens, Beth.

Annu Rev Cell Dev Biol ; 34: 523-544, 2018 10 06.

Artigo em Inglês | MEDLINE | ID: mdl-30089221

3.

Immune Signaling in Neurodegeneration.

Hammond, Timothy R; Marsh, Samuel E; Stevens, Beth.

Immunity ; 50(4): 955-974, 2019 04 16.

Artigo em Inglês | MEDLINE | ID: mdl-30995509

4.

Single-Cell RNA Sequencing of Microglia throughout the Mouse Lifespan and in the Injured Brain Reveals Complex Cell-State Changes.

Hammond, Timothy R; Dufort, Connor; Dissing-Olesen, Lasse; Giera, Stefanie; Young, Adam; Wysoker, Alec; Walker, Alec J; Gergits, Frederick; Segel, Michael; Nemesh, James; Marsh, Samuel E; Saunders, Arpiar; Macosko, Evan; Ginhoux, Florent; Chen, Jinmiao; Franklin, Robin J M; Piao, Xianhua; McCarroll, Steven A; Stevens, Beth.

Immunity ; 50(1): 253-271.e6, 2019 01 15.

Artigo em Inglês | MEDLINE | ID: mdl-30471926

5.

Author Correction: Schizophrenia risk from complex variation of complement component 4.

Sekar, Aswin; Bialas, Allison R; de Rivera, Heather; Davis, Avery; Hammond, Timothy R; Kamitaki, Nolan; Tooley, Katherine; Presumey, Jessy; Baum, Matthew; Van Doren, Vanessa; Genovese, Giulio; Rose, Samuel A; Handsaker, Robert E; Daly, Mark J; Carroll, Michael C; Stevens, Beth; McCarroll, Steven A.

Nature ; 601(7892): E4-E5, 2022 Jan.

Artigo em Inglês | MEDLINE | ID: mdl-34912127

6.

Schizophrenia risk from complex variation of complement component 4.

Sekar, Aswin; Bialas, Allison R; de Rivera, Heather; Davis, Avery; Hammond, Timothy R; Kamitaki, Nolan; Tooley, Katherine; Presumey, Jessy; Baum, Matthew; Van Doren, Vanessa; Genovese, Giulio; Rose, Samuel A; Handsaker, Robert E; Daly, Mark J; Carroll, Michael C; Stevens, Beth; McCarroll, Steven A.

Nature ; 530(7589): 177-83, 2016 Feb 11.

Artigo em Inglês | MEDLINE | ID: mdl-26814963

7.

Intranasal epidermal growth factor treatment rescues neonatal brain injury.

Scafidi, Joseph; Hammond, Timothy R; Scafidi, Susanna; Ritter, Jonathan; Jablonska, Beata; Roncal, Maria; Szigeti-Buck, Klara; Coman, Daniel; Huang, Yuegao; McCarter, Robert J; Hyder, Fahmeed; Horvath, Tamas L; Gallo, Vittorio.

Nature ; 506(7487): 230-4, 2014 Feb 13.

Artigo em Inglês | MEDLINE | ID: mdl-24390343

8.

Therapeutic inhibition of ferroptosis in neurodegenerative disease.

Ryan, Sean K; Ugalde, Cathryn L; Rolland, Anne-Sophie; Skidmore, John; Devos, David; Hammond, Timothy R.

Trends Pharmacol Sci ; 44(10): 674-688, 2023 10.

Artigo em Inglês | MEDLINE | ID: mdl-37657967

9.

Microglia ferroptosis is regulated by SEC24B and contributes to neurodegeneration.

Ryan, Sean K; Zelic, Matija; Han, Yingnan; Teeple, Erin; Chen, Luoman; Sadeghi, Mahdiar; Shankara, Srinivas; Guo, Lilu; Li, Cong; Pontarelli, Fabrizio; Jensen, Elizabeth H; Comer, Ashley L; Kumar, Dinesh; Zhang, Mindy; Gans, Joseph; Zhang, Bailin; Proto, Jonathan D; Saleh, Jacqueline; Dodge, James C; Savova, Virginia; Rajpal, Deepak; Ofengeim, Dimitry; Hammond, Timothy R.

Nat Neurosci ; 26(1): 12-26, 2023 01.

Artigo em Inglês | MEDLINE | ID: mdl-36536241

10.

The Role of the Complement System in Chronic Inflammatory Demyelinating Polyneuropathy: Implications for Complement-Targeted Therapies.

Querol, Luis A; Hartung, Hans-Peter; Lewis, Richard A; van Doorn, Pieter A; Hammond, Timothy R; Atassi, Nazem; Alonso-Alonso, Miguel; Dalakas, Marinos C.

Neurotherapeutics ; 19(3): 864-873, 2022 04.

Artigo em Inglês | MEDLINE | ID: mdl-35378684

11.

Dissection of artifactual and confounding glial signatures by single-cell sequencing of mouse and human brain.

Marsh, Samuel E; Walker, Alec J; Kamath, Tushar; Dissing-Olesen, Lasse; Hammond, Timothy R; de Soysa, T Yvanka; Young, Adam M H; Murphy, Sarah; Abdulraouf, Abdulraouf; Nadaf, Naeem; Dufort, Connor; Walker, Alicia C; Lucca, Liliana E; Kozareva, Velina; Vanderburg, Charles; Hong, Soyon; Bulstrode, Harry; Hutchinson, Peter J; Gaffney, Daniel J; Hafler, David A; Franklin, Robin J M; Macosko, Evan Z; Stevens, Beth.

Nat Neurosci ; 25(3): 306-316, 2022 03.

Artigo em Inglês | MEDLINE | ID: mdl-35260865

12.

A map of transcriptional heterogeneity and regulatory variation in human microglia.

Young, Adam M H; Kumasaka, Natsuhiko; Calvert, Fiona; Hammond, Timothy R; Knights, Andrew; Panousis, Nikolaos; Park, Jun Sung; Schwartzentruber, Jeremy; Liu, Jimmy; Kundu, Kousik; Segel, Michael; Murphy, Natalia A; McMurran, Christopher E; Bulstrode, Harry; Correia, Jason; Budohoski, Karol P; Joannides, Alexis; Guilfoyle, Mathew R; Trivedi, Rikin; Kirollos, Ramez; Morris, Robert; Garnett, Matthew R; Timofeev, Ivan; Jalloh, Ibrahim; Holland, Katherine; Mannion, Richard; Mair, Richard; Watts, Colin; Price, Stephen J; Kirkpatrick, Peter J; Santarius, Thomas; Mountjoy, Edward; Ghoussaini, Maya; Soranzo, Nicole; Bayraktar, Omer A; Stevens, Beth; Hutchinson, Peter J; Franklin, Robin J M; Gaffney, Daniel J.

Nat Genet ; 53(6): 861-868, 2021 06.

Artigo em Inglês | MEDLINE | ID: mdl-34083789

13.

Embryonic transcription factor expression in mice predicts medial amygdala neuronal identity and sex-specific responses to innate behavioral cues.

Lischinsky, Julieta E; Sokolowski, Katie; Li, Peijun; Esumi, Shigeyuki; Kamal, Yasmin; Goodrich, Meredith; Oboti, Livio; Hammond, Timothy R; Krishnamoorthy, Meera; Feldman, Daniel; Huntsman, Molly; Liu, Judy; Corbin, Joshua G.

Elife ; 62017 03 13.

Artigo em Inglês | MEDLINE | ID: mdl-28244870

14.

Endothelin-B Receptor Activation in Astrocytes Regulates the Rate of Oligodendrocyte Regeneration during Remyelination.

Hammond, Timothy R; McEllin, Brian; Morton, Paul D; Raymond, Matthew; Dupree, Jeff; Gallo, Vittorio.

Cell Rep ; 13(10): 2090-7, 2015 Dec 15.

Artigo em Inglês | MEDLINE | ID: mdl-26628380

15.

Astrocyte-derived endothelin-1 inhibits remyelination through notch activation.

Hammond, Timothy R; Gadea, Ana; Dupree, Jeff; Kerninon, Christophe; Nait-Oumesmar, Brahim; Aguirre, Adan; Gallo, Vittorio.

Neuron ; 81(3): 588-602, 2014 Feb 05.

Artigo em Inglês | MEDLINE | ID: mdl-24507193

16.

Increasing the neurological-disease toolbox using iPSC-derived microglia.

Hammond, Timothy R; Stevens, Beth.

Nat Med ; 22(11): 1206-1207, 2016 11 08.

Artigo em Inglês | MEDLINE | ID: mdl-27824814

17.

Astrocyte-Derived Endothelin-1 Inhibits Remyelination through Notch Activation.

Hammond, Timothy R; Gadea, Ana; Dupree, Jeff; Kerninon, Christophe; Nait-Oumesmar, Brahim; Aguirre, Adan; Gallo, Vittorio.

Neuron ; 81(6): 1442, 2014 Mar 19.

Artigo em Inglês | MEDLINE | ID: mdl-28898632

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